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Anticoagulants: Phenobarbital lowers the plasma levels of dicumarol (identify Beforehand used: bishydroxycoumarin) and results in a decrease in anticoagulant action as measured via the prothrombin time. Barbiturates can induce hepatic microsomal enzymes leading to elevated metabolism and lowered anticoagulant reaction of oral anticoagulants (e.It's